Symptomatic malignant pleural effusion patients Pleurodesis,
Conditions
Interventions
Using aseptic techniques,
obtained 100 ml of the patient’s blood via brachial vein by nurse,
then immediately instilled the blood into the chest tube by doctor.,Instillation of 20 ml of 1% xylocaine without adrenaline with NSS injection up to 50 ml into the chest tube and wait for 5 minutes.
10 minutes.
Autologous blood,Talc
Sponsors
Human Research Ethic Committee
Faculty of Medicine,
Prince of Songkla University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients 18 years of age and older - Symptomatic MPE (cytologically or histologically confirmed) patients - Life expectancy of more than 3 months - Good lung expansion after drainage of pleural fluid with approximation of visceral and parietal pleura - Agreement to receive chemical pleurodesis for treatment of MPE
Exclusion criteria
Exclusion criteria: - Any pleural or systemic infection - Hemodynamic instability - Hemothorax (pleural fluid over serum hematocrit > 50%) - Serum hematocrit < 25% - Chylothorax - Combination of causes of pleural effusion - History of talc or lidocaine allergy - Chest X ray showing trapped lung after chest tube drainage - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the efficacy of autologous blood pleurodesis Versus Talc pleurodesis at 1 month Chest radiograph | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate safety of autologous blood pleurodesis Versus Talc pleurodesis upto 1 week Pain score, fever | — |
Contacts
Public ContactWARANGKANA KEERATICHANANONT
Faculty of Medicine, Prince of Songkla University
Outcome results
None listed