unilateral total knee arthroplasty
Conditions
Interventions
During intraoperative period,
before the cement is applied,
the periarticular injection with a mixture containing 10 ml of 0.5%levobupivacaine,
1 ml of 3%ketorolac,
0.2 ml of 0.2 ml of 0.1%epinephrine and 38.8 ml of 0.9%NaCl will be administered. For a total of 50 ml of this study drug,
30 ml will be injected into the posterior joint capsule and 20 ml will be injected around the lateral collateral ligament. ,The periarticular injection will not be administered in this group.
Experimental Drug,Placebo Comparator Drug
periarticular injection (PI),no periarticular injection (NPI)
Sponsors
Chaophraya Yommarat Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: - ASA physical status I-III - Age 20-75 years old - Body weight ≥45 kgs.
Exclusion criteria
Exclusion criteria: - unable to evaluate visual analogue scale (VAS) of pain - unable to use patient-controlled analgesia (PCA) device - contraindications to spinal anesthesia or CFNB (coagulopathy, progressive neurological deficit, intracranial space occupying lesion, unstable hemodynamic state, local infection at site of injection and patient refusal) - allergy to any drugs used in this study - inadequate level of spinal anesthesia or CFNB - start case after 12.00 a.m.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 48 hours postoperative morphine consumption 48 hours after the operation record morphine consumption by using PCA device in milligram | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative morphine consumption during 0 - 4, 4 - 8, 8 - 24, 24 - 48 and 0 - 24 hours interval 0 - 4, 4 - 8, 8 - 24, 24 - 48 and 0 - 24 hours after the operation record morphine consumption by using PCA device in each time in milligram,Pain score at rest, 45 degree knee flexion, maximal knee flexion and sitting on the morning of POD1 on the morning of postoperative day 1 and postoperative day 2 record VAS in millimeter,Range of motion on the morning of POD1 and POD2 on the morning of postoperative day 1 and postoperative day 2 by using goniometer in degree,Side effects 48 hours after the operation using a questionnaire interview in yes or no | — |
Countries
Thailand
Contacts
Public ContactPhetprapa Thongsrichan
Chaophraya Yommarat Hospital
Outcome results
None listed