Parenteral parecoxib provides similar analgesic efficacy to single-shot sciatic nerve block after total knee arthroplasty when combined with continuous femoral nerve block

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20150608001

Enrollment

Unknown

Registered

2015-06-08

Start date

2010-10-04

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Arthroplasty (TKA) Parecoxib Total knee arthroplasty Sciatic nerve block

Interventions

Parenteral parecoxib is known to have opioid&#45

sparing effects and has been shown to be well tolerated while improving range of motion after TKA,Continuous femoral nerve block

Active Comparator Procedure/Surgery,No Intervention Procedure/Surgery

Parenteral parecoxib,Continuous femoral nerve block

Eligibility

Sex/Gender

All

Age

0 Years to 100 Years

Inclusion criteria

Inclusion criteria: - Adults undergoing unilateral TKA - Written informed consent obtained

Exclusion criteria

Exclusion criteria: - Infection at the planned site of skin puncture, coagulopathy, known allergy to local anesthetics, and inability to operate a patient-controlled analgesia device (PCA). Patients with relative contraindications to intravenous parecoxib, such as coronary artery disease, cerebrovascular disease, asthma and severe renal function impairment.

Design outcomes

Primary

Measure	Time frame
Morphine requirement first 24 hours Morphine consumption (mg)	—

Secondary

Measure	Time frame
Time to first analgesic dose No Duration (min)	—

Countries

Thailand

Contacts

Public ContactNuj Tontisirin

Department of Anesthesiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University

doctornuj@gmail.com66 2201 1523

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Parenteral parecoxib provides similar analgesic efficacy to single&#45;shot sciatic nerve block after total knee arthroplasty when combined with continuous femoral nerve block