Attenuation of hemodynamic responses to laryngoscopy and intubation in hypertensive patients: Fentanyl versus Morphine plus Lidocaine

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20150607001

Enrollment

Unknown

Registered

2015-06-07

Start date

2015-07-27

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertensive patients who undergoing general anesthesia with tracheal intubation Fentanyl Lidocaine Hypertensive patients Hemodynamic response Intubation

Interventions

&#45

Fentanyl 2 mcg/kg dilute to 10 ml with normal saline IV at 5 minutes before intubation(3 minutes before induction) &#45

NSS 10 ml IV at 3 minutes before intubation &#45

Induction with propofol 2.5 mg/kg IV &#45

Intubation with succinylcholine 1.5 mg/kg IV(1 minute prior laryngoscopy and intubation) ,&#45

Morphine 0.1 mg/kg dilute to 10 ml with normal saline IV at 5 minutes before intubation &#45

Lidocaine 1.5 mg/kg dilute to 10 ml with normal saline IV at 3 minutes before intubation (1 minutes before induction) &#45

Intubation with succinylcholine 1.5 mg/kg IV(1 minute prior laryngoscopy and intubation)

Active Comparator Drug,Active Comparator Drug

Fentanyl group,Conventional group

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age between 40-65 years old 2.Hypertensive patients (controlled BP < 160/90 mmHg) ASA physical status II or III 3.Elective surgery requiring general anesthesia with tracheal intubation 4.Written informed consent obtained

Exclusion criteria

Exclusion criteria: 1.Cardiac surgery 2.Pregnancy 3.Obesity (body mass index > 30) 4.Expected difficult intubation 5.Nasogastric tube insertion 6.Taking beta-blockers 7.Significant medical co-morbidities (coronary artery disease, congestive heart failure, cardiac arrhythmia) 8.Contraindication/precaution to lidocaine use (eg. evidence of heart block ) 9.Contraindication/precaution to morphine use (eg. asthma, COPD, chronic kidney disease stage 3 /GFR < 60 ml/min/1.73m2) 10.Allergy to study drugs

Design outcomes

Primary

Measure	Time frame
successfully controlled hemodynamic responses baseline, 1 minute after intubation Systolic blood pressure (SBP) and heart rate (HR)	—

Secondary

Measure	Time frame
adverse events baseline, just before intubation, immediately after intubation, and every 1 minute unt Systolic blood pressure (SBP) and heart rate (HR)	—

Countries

Thailand

Contacts

Public ContactRaweeporn Laopakdee

Khon Kaen Hospital

chang.pm@hotmail.com66819336756

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026