Allergic rhinitis Dust mite allergy Allergic rhinitis Cellulose powder Dust mite allergy Total nasal symptoms score Nasal provocation test Rhinomanometry PNIF
Conditions
Interventions
Cellulose powder spray from natural origin,
delivered through a patented delivery system. It is a medical device indicated in the prevention of airborne allergies.
,Placebo is made from lactose powder. It'
s safe for using via intranasal route.
It is made to resemble drugs
both packaging and labelling
Cellulose powder,Placebo (Lactose powder)
Sponsors
Clinical Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Allergy and Immunology Unit,
Department of Pediatrics,
Ramathibodi
Eligibility
Sex/Gender
All
Age
8 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age 8-18 years old 2. Have persistent rhinitis symptoms for a minimum of 1 year 3. Positive skin prick test (SPT) for house dust mite allergen (D.pteronyssinus) 4. Positive nasal challenge test for D.pteronyssinus
Exclusion criteria
Exclusion criteria: 1. Patients with asthma, upper respiratory tract infections or nasal deformities 2. Patients with multiple sensitization from SPT 3. Received and receiving allergen immunotherapy 4. Patients with severe persistent AR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical symptoms of AR before and after treatment with cellulose powder 1 month after treatment with cellulose powder/placebo TNSS, Severity of clinical symptoms during nasal challenge, PNIF, Anterior Rhinomanometry | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory response before and after treatment with cellulose powder 1 month after treatment with cellulose powder/placebo Nasal scraping for cellular analysis before and after treatment | — |
Countries
Thailand
Contacts
Public ContactNatchanun Klangkalya
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed