Vulvovaginal symptom postmenopausal women vaginal dryness pueraria mirifica vaginal cytology lactobacillus grading
Conditions
Interventions
Pueraria mirifica gel extract from Kwao Krua Kao,
A Thai herb that was popular and had been used as an elixir for a hundred years.,A local vaginal estrogen cream which FDA approved for treatment of vulvovaginal symptoms
Experimental Drug,Active Comparator Drug
Narathorn Suwanvesh,Narathorn Suwanvesh
Sponsors
Faculty of Medicine, Ramathibodi Hospital
Faculty of Medicine,
Ramathibodi Hospital
Eligibility
Sex/Gender
Female
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: A healthy postmenopausal women who 1. aged 40-75 years 2. last menstrual period at least one year before 3. intact uterus 4. have at least one of vulvovaginal symptom; dryness, soreness, irritation, dyspareunia or abnormal discharge 5. no contraindication for hormone therapy 6. no history of breast and any hormonal sensitive cancer
Exclusion criteria
Exclusion criteria: A women who 1. want to withdraw from the study 2. treatment adherence less than 80%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vaginal Maturation Index 1st visit, 6-week and 12-week Vaginal cytology for assessing maturation index | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal symptom score 1st visit, 6-week, 12-week Questionaire,Vaginal assessment score 1st visit, 6-week, 12-week Pelvic examination and scored by examiner,Lactobacillus grading 1st visit, 12-week Vaginal smear for Gram stain | — |
Countries
Thailand
Contacts
Public ContactNarathorn Suwanvesh
Ramathibodi Hospital
Outcome results
None listed