Allergy,
Conditions
Interventions
5 mg of levocetrizine,
or 180 mg of fexofenadine,
or 5 mg of desloratadine,This study is a cross-
over design,
the volunteers will received three cross-
over comparative intervention with a 7-
days was-
out prior to each cross-
over experiment.
placebo is used for levocetirizine and desloratadine.
Remark: but in case faexofenadine due to the size of the tablet can not fit into the standard placebo capsule ,
thus in the control arm it is with no-
intervention,
but the evaluator is blinded to avoid bias
Active Comparator Drug,Placebo Comparator Drug
Levocetirizine or fexofenadine or desloratadine,placebo
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) male or female who is 15-65 years old, (2) documented diagnosis of allergic rhinitis with remarkably positive skin prick test (as defined by mean diameter was at least 5 mm. with/without pseudopod) for house dust mite or American cockroach, (3) no concomitant drug used, (4) no steroid or its derivatives intake at least 4 weeks prior to the study, (5) never undergone immunotherapy and (6) understand and agree with all steps in the study.
Exclusion criteria
Exclusion criteria: (1) having other concomitant medical conditions except for mild severity of atopic diseases, (2) pregnant or breastfeeding, (3) having the history of anaphylaxis or severe allergic response to skin prick test with house dust mite or cockroach, ( 4) dependent on antihistamine and cannot stop using it due to exacerbation of disease and (5) history of severe allergic response to levocetrizine, fexofenadine or desloratadine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| allergen-induced skin wheal and flare at 7 days of the treatment size in millimetre of the wheal and flare diameters | — |
Secondary
| Measure | Time frame |
|---|---|
| histamine-induced skin wheal and flare at 7 days of the treatment size in millimetre of the wheal and flare diameters,nasal symptoms at 7 days of the treatment total nasal symtom score | — |
Countries
Thailand
Contacts
Public ContactKiat Ruxrungtham
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed