advert event and number of patients Helicobacter pylori eradication
Conditions
Interventions
one week tailored triple therapy (esomeprazole 20 mg bid,
clarithromycin 500 mg bid or metronidazole 400 mg tid if clarithromycin resistance and amoxicillin 1000 mg bid
group1,
n = 100)
one week of pre-
treatment with probiotics (group2,
n = 100),one week of pre-
treatment with probiotics (Lactobacillus delbrueckii and Streptococcus thermophillus),one week of pre-
treatment probiotic before tailored triple therapy then followed by one weeks of the same probiotics after treatment with tailored triple therapy (Lactobacillus delbrueckii and Streptococcus thermophi
Placebo Comparator Drug,Experimental Dietary Supplement,Experimental Dietary Supplement
tailored triple therapy alone,one week of pre-
treatment with probiotics,one week of pre-
treatment probiotic before tailored triple therapy then followed by one weeks of the
Sponsors
institute of reserch and development, Suranaree University of Technology
Suranaree University of Technology Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Helicobacter pylori associated gastritis
Exclusion criteria
Exclusion criteria: age below 18 or above 70 years, previous Helicobacter pylori eradication treatment before previous 2 months, gastric ulcer or duodenal ulcer, suspected or confirmed malignancy on endoscopy, significant medical illnesses and history of previous gastric surgery, pregnant or lactating women, and the use of antimicrobials or gastrointestinal medications like PPIs or bismuth compounds within the previous 2 months, refuse yogurt due to underlying disease such as DM ,history of drug allergy in first line therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Administration of probiotic to pre-treatment and post-treatment tailored triple therapy can improve 1 month after treatment eradication rate after complete theraputic protocal | — |
Secondary
| Measure | Time frame |
|---|---|
| advert event during thraputic peroid 1 month after treatment number and percent of advert event during treatment | — |
Countries
Thailand
Contacts
Public Contacttaweesak tongtawee
department of surgery
Outcome results
None listed