healthy human volunteers
Conditions
Interventions
All healthy volunteers was fasting for 12 hour before received 2 g of Andrographis paniculata capsules for 3 times in 4 hour intervals. Compared the effects of Andrographis paniculata before and after
Active Comparator Drug
Sponsors
Faculty of Medicine Siriraj Hospital
Faculty of Medicine Siriraj Hospital
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Male or female age between 25-60 years 2. Body mass index (BMI) between 18 to 24 kg/m^2 3. Who has been determined healthy physical examination, medical history, and vital signs 4. Female, non pregnant or use the contraceptive or not currently breast feeding and have negative pregnancy test 5. Who be willing to participate and signed the informed consent form
Exclusion criteria
Exclusion criteria: 1. Who has history usage of other drugs, especially which can effect platelet aggregation 2. Who has history of allergic reactions or allergy to NSAIDs, Andrographis paniculata or its derivative compounds 3. Who is no smoke and alcohol 4. Who has donated blood within last 90 days before participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A. paniculata has the effect on platelet aggregation in human platelet 0, 2, and 24 hour after A. paniculata administration aggregation assay | — |
Secondary
| Measure | Time frame |
|---|---|
| A. paniculata has the effect on COX activity and P-selectin in human platelet aggregation 0, 2, and 24 hour after A. paniculata administration RT-PCR, Western blot and ELISA | — |
Countries
Thailand
Contacts
Public ContactAssoc. Prof. Pravit Akarasereenont
Faculty of Medicine Siriraj Hospital
Outcome results
None listed