knee osteoarthritis knee osteoarthritis capsaicin patch
Conditions
Interventions
capsaicin patch over acupuncture point of the knee,placebo patch over acupuncture point of the knee
Experimental Drug,Placebo Comparator Other
capsaicin patch,placebo patch
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosis of idiopathic OA knee according to clinical criteria of American College of Rheumatology Knee pain + at least 3 of 6: o Age > 50 years o morning stiffness< 30 minutes o crepitus o bony tenderness o bony enlargement o no palpable warmth 2. Ambulatory patient aged more than 50 years 3. Pain score according to numerical rating scale (while standing) 4-7 out of 10 4. Willing to participate
Exclusion criteria
Exclusion criteria: 1. History of hypesensitivity to capsaicin or related compound, paracetamol, naproxen and NSAIDs 2. Skin lesion at the index (treated) knee 3. History of acupuncture within 1 month prior to screening 4. History of lower extremity surgery within 6 months prior to screening 5. Other rheumatologic disease such as rheumatoid arthritis, gout 6. Disease of lower limb or spine that affect patient ambulation 7. Treatment with other drugs potentially affecting bone or cartilage metabolism, such as : o Chronic systematic corticosteroids o Glucosamine or chondroitin sulphate within 15 day prior to screening o Hyaluronate injection into the index knee within 6 months prior to screening o Diacerin treatment within 12 months prior to screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Thai version of WOMAC osteoarthritis index for knee OA (pain subscale) 0,2,4,6,8 week modified Thai version of WOMAC osteoarthritis index for knee OA | — |
Secondary
| Measure | Time frame |
|---|---|
| modified Thai version of WOMAC osteoarthritis index for knee OA (stiffness and physical function) 0,4,8 week modified Thai version of WOMAC osteoarthritis index for knee OA | — |
Countries
Thailand
Contacts
Public ContactChayaporn Chotiyarnwong
Department of physical medicine and rehabilitation, faculty of medicine, Siriraj hospital
Outcome results
None listed