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The effect of dexmedetomidine infusion on post-operative cognitive function and oxidative stress in patients undergo cardiopulmonary bypass machine facilitated elective cardiac surgery.

The effect of dexmedetomidine infusion on post-operative cognitive function and oxidative stress in patients undergo cardiopulmonary bypass machine facilitated elective cardiac surgery.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20141110003
Enrollment
Unknown
Registered
2014-11-10
Start date
2014-11-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post&#45

Interventions

0.4 microgram per kilograms of Dexmedetomidine will be given slowly intravenously in 20 minutes for the bolus dose then 0.5 microgram per kilogram per hour for continuous infusion until end of surgery
Experimental Drug,Placebo Comparator Drug
dexmeditomidine,nornal saline

Sponsors

TRF
Lead Sponsor
Faculty of Medicine&#44
Collaborator
Chulalongkorn University
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The patient, whose age between 18 and 65 years, scheduled for cardiopulmonary bypass facilitated elective cardiac surgery

Exclusion criteria

Exclusion criteria: allergic to any drug in research protocol left ventricular ejection fraction less than 30% pre-operative severe hypotension (mean arterial pressure less than 60 mmHg) pre-operative severe bradycardia (heart rate of less than 45 beat per minute) co-existing psychological disorder unable to take cognitive function test.

Design outcomes

Primary

MeasureTime frame
Postoperative Cognitive Function 24 hour and 1 week post-operatively cognitive function test,Oxidative Stress and Inflammatory response preoperative, post-cardiopulmonary bypass machine termination, ICU admission, 24 hours Blood for hs-CRP, TNF-α, IL-6 and IL-10—

Secondary

MeasureTime frame
Post-operative Complication preoperative until discharged home data extraction from medical record—

Countries

Thailand

Contacts

Public ContactToonchai Indrambarya

department of Anesthesiology, Faculty of Medicine, Chulalongkorn University

toonchai@hotmail.com6622564295

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026