Phenylephrine-
Conditions
Interventions
Treatment
Sponsors
Graduate school Chulalongkorn university
9oth Anniversary of Chulalongkorn University Scholarship
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: - ASA I,II - Age greater than or equal 18 years old. - Singleton baby. - Gestational age greater than or equal to 37 weeks
Exclusion criteria
Exclusion criteria: Chronic hypertension, gestational hypertension or preeclampsia. - Cardiovascular disease (ischemic heart disease, valvular heart disease, cardiac defect) or cerebrovascular disease (stroke, cerebral aneurysm, cerebral arteriovenous malformation) - Complicated obstetrics (abruptio placenta, placenta previa) - Known fetal abnormalities (intrauterine growth retardation(IUGR), fetal cardiac disease) - History use of monoamine oxidase inhibitor(MAOI). - History use of other drugs that prolonged heart conduction(PR or QT interval) - Contraindications to spinal anesthesia (coagulopathy, intracranial space occupying lesion or patient refusal)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidences of phenylephrine-induced bradycardia in treatment of spinal anesthesia-induced hypotensio End of study Percentage | — |
Secondary
| Measure | Time frame |
|---|---|
| Association of pretherapeutic heart rate and phenylephrine-induced bradycardia End of study Relative risk,The optimal cut-point of heart rate that safe for using phenylephrine End of study Multivariable logistic regression,The incidences of severe adverse events End of study Percentage | — |
Countries
Thailand
Contacts
Public ContactRatikorn Anusorntanawat
Chaoprayayomraj hospital
Outcome results
None listed