A Study: Comparison between Positive Rates of Autologous Serum Skin Test and Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20140822001

Enrollment

Registered

2014-08-22

Start date

2014-09-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic spontaneous urticaria Autologous serum skin test ASST Autologous plasma skin test APST Basophil histamine release assay BHRA AntiFcERIa autoantibody Chronic spontaneous urticaria CSU Autoimmune chronic spontaneou

Interventions

&#45

Autologous serum skin test and autologous plasma skin test using the sera and plasma of the patients&#44

injected intradermally on the velar forearms compared with saline injection as negative control. The positive result is identified if the wheal response from sera/ plasma is 1.5 mm or more compared wi

Sera from all the chronic spontaneous patients enrolled in this study are tested for basophil histamine release assay and antiFcERIa antibody assay

Active Comparator Other

Autologous serum and plasma skin test

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: chronic spontaneous urticaria patient with active symptoms rash for 2 days week or more age 18 80 years

Exclusion criteria

Exclusion criteria: pregnancy or lactation history of rash on velar forearms within 48 hours before testing on any antihistamine within 3 days prior to the test 4 days for Dexchlorpheniramine levocetirizine 7 days for Azelastine Loratadine or other long acting antihistamines 2 weeks for doxepin history of potent topical steroids class 1 3 application on the volar forearms or systemic corticosteroid dosing equivalent to prednisolone 15 mg d within 7 days prior to the test have physical urticaria or dermatographism have urticarial vasculitis urticaria from other autoimmune connective tissue disease autoimmune progesterone urticaria or positive progesterone intradermal testing have abnormal CBC hepatitis virus infection abnormal stool examination urinary analysis chest radiograph rheumatoid factor level or antinuclear antibody titer more than 1 80

Design outcomes

Primary

Measure	Time frame
positive rates of the autologous serum skin test compared with the autologous plasma skin test 30 min after intradermal injection wheal response to autologous serum/ plasma 1.5 mm or more compared with saline	—

Secondary

Measure	Time frame
accuracy of ASST compared with APST in detecting positive BHRA, antiFcERIa antibody - sensitivity, specificity, predictive values, accuracy,agreement between BHRA and antiFcERIa in chronic spontaneous urticaria - Cohen's kappa coefficient	—

Contacts

Public ContactJayne Areejunthawat

Chulalongkorn university

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026