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Effect of acemannan, a polysaccharide extracted from aloe vera gel, on periodontium regeneration in periodontitis patient, a randomized clinical study

Effect of acemannan, a polysaccharide extracted from aloe vera gel, on periodontium regeneration in periodontitis patient, a randomized clinical study

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20140621001
Enrollment
20
Registered
2014-06-21
Start date
2015-04-04
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non smoking/pregnant during study No systemic disease that interfere healing of periodntal tissue Patient with a three walls defect of periodontal pocket acemannan aloe vera 3 wall&#45

Interventions

This membrane has been used to protect the underlying connective tissue from invading bacteria&#44
food debris&#44
and ingrowth epithelium. So&#44
the underlying bone forming cell&#44
periodontal ligament cell&#44
and cementum forming cell can freely perform to produce their tissues.,Acemannan sponge functions as a temporary scaffold for blood clot formation and biological active molecule to stimulates bone for
and cementum forming cell to regenerate bone&#44
periodontal ligament&#44
and cementum. So&#44
the tooth can physiologically function.
Active Comparator Device,Active Comparator Biological/Vaccine
Guide tissue regeneration membrane,acemannan sponge

Sponsors

National Research Council of Thailand
Lead Sponsor
Chulalongkorn University
Collaborator

Eligibility

Sex/Gender
All
Age
35 Years to 55 Years

Inclusion criteria

Inclusion criteria: Three wall bony defect of periodontal pocket Patient have a good oral hygience status

Exclusion criteria

Exclusion criteria: Cannot attend through the study Pregnant Heavy alcohol drinking Systematic disease that interfere the treatment or periodontium healing

Design outcomes

Primary

MeasureTime frame
increasment of a tooth supporting bone 6, 12 and 24 month radiography and forming bone density

Secondary

MeasureTime frame
decrease of periodontal pocket 3, 6, 12 and 24 month radiography and measurement

Countries

Thailand

Contacts

Public ContactPennapha Karawake

Chulalongkorn University

pakka_19@hotmail.com0854036326

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026