Patients presenting with acute dyspnea and hypoxemia in an emergency room Dyspnea Hypoxemia Emergency room Oxygen therapy
Conditions
Interventions
In HFNC group,
oxygen is delivered with an inspiratory flow rate at 35 L/min and FiO2 is adjusted to achieve SpO2 ≥
94% within first 5 minutes and continued for 60 minutes,In the COT group,
100% oxygen is applied via a nasal cannula or a non-
rebreathing mask with flow rate between 3-
10 L/min to maintained SpO2 ≥
94% for 60 minutes.
Experimental Device,Active Comparator Device
flow nasal oxygen cannula,conventional oxygen therapy
Sponsors
Faculty of Medicine Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patients aged 18 years or older who develop acute dyspnea with hypoxemia breathing frequency 24 min and oxygen saturation from pulse oximetry SpO2 94 at room air
Exclusion criteria
Exclusion criteria: 1 hemodynamic instability 2 needed invasive mechanical ventilation 3 chronic respiratory failure with long term oxygen supplementation 4 decreased level of consciousness Glasgow Coma Scale 13 5 uncooperative 6 pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Benefit of HFNC on breathing frequency 60 minutes breath/minute | — |
Secondary
| Measure | Time frame |
|---|---|
| Dyspnea level 60 minutes visual analog scale,Patient comfort level 60 minutes visual analog scale,Adverse event 60 minutes number of reported adverse event,Effects on other physiologic parameters 60 minutes mean arterial pressure (mmHg), heart rate (beat/min) | — |
Countries
Thailand
Contacts
Public ContactNuttapol Rittayamai
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed