Meibomian gland dysfunction Doxycycline,
Conditions
Interventions
1.5% Azithromycin eye drop to affected eye twice daily 2 days then 1 drop daily for 4 weeks,Doxycycline 100 mg twice daily for 4 weeks
Experimental Drug,Active Comparator Drug
1.5% Azithromycin eye drop,Doxycycline 200 mg daily
Sponsors
Falculty of medicine , Chulalongkorn University
Falculty of medicine ,
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 Patients age at least 18 years old 2 Patients who are diagnosed meibomian gland dysfunction at least stage 3 by corneal specialist in King Chulalongkorn Memorial Hospital
Exclusion criteria
Exclusion criteria: 1 History of allergic to tetracycline tetracycline derivatives or macrolide 2 History of allergic to fluorescein or tetracaine eye drop 3 Ocular surface inflammation either infection or non infection causes except meibomian gland dysfunction origin at the time of study 4 Punctal occlusion is used at the time of study 5 Pregnancy lactation or preparing for pregnancy either pre study or at the time of study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patients whose meibum quality improved from level 3 to 1 or 4 to 1-2 4 weeks meibum in each 8 glands in the middle of lower eyelid by meibum expression instrument | — |
Secondary
| Measure | Time frame |
|---|---|
| Meibum expression 4 weeks counting number from 5 glands of meibomian glands which express meibum by upper or lower eyelid pres,Safety 4 weeks percentage of patients who have side effects from doxycycline and azithromycin,Symptoms 4 weeks 3 symptoms of MGD in discomfort, itching, and photophobia,Tear film stability 4 weeks Averaged tear break up time,Ocular surface staining 4 weeks Calculated via Oxford staining score | — |
Countries
Thailand
Contacts
Public ContactKitiya Ratanawongphaibul
Chulalongkorn university
Outcome results
None listed