patients undergoing abdominal hysterectomy with or without ovarian surgery melatonin postoperative pain preemptive analgesia hysterectomy
Conditions
Interventions
melatonin 4 mg night and 2 hours before operation ,Placebo at the same time point as treatment group
Experimental Drug,Placebo Comparator Drug
4 mg of prolong-
released melatonin,Placebo
Sponsors
Ratchadapisek Somphot fund
Chulalongkorn University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1 patients undergoing abdominal hysterectomy with or without ovarian surgery 2 choice of anesthesia is spinal anesthesia 3 age 18 65 years old 4 American physical status class 1 2 5 elective surgery
Exclusion criteria
Exclusion criteria: 1.history of allergy to medications in the study 2.mental diseases 3.chronic pain 4.concurrent other anxiolytic or sedative drugs use 5.inability to PCA use 6.severe cardiac, liver or kidney diseases 7.history of suspected obstructive sleep apnea 8.obesity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postopoerative morphine consumption first 24 hours morphine consumption from patient-controlled-analgesia machine | — |
Secondary
| Measure | Time frame |
|---|---|
| pain score recovery room arrival, 1, 6, 24 hour after surgery visual analog scale score,Satisfaction score 24 hour after surgery visual analog scale score,Postoperative anxiety pre operative and 24 hour posterative Amsterdam Preoperative Anxeity and Informationn Scale, Thai version,Postoperative sleep quality pre and 24 hour postoperative visual analog scale score,Postoperative fatigue level pre and 24 hour postoperative visual analog scale score,Postoperative genral well being pre and 24 hour postoperative visual analog scale score,Adverse events and complication Intraoperative and 24 hour postoperative Incidence | — |
Contacts
Public ContactProk Laosuwan
Chulalongkorn University
Outcome results
None listed