Mild to Moderate Knee Osteoarthritis Bromelain,
Conditions
Interventions
Active Comparator Drug,Active Comparator Drug
Diclofenac treatment,Bromelain treatment
Sponsors
Department of Pharmacology, Faculty of Science, Mahidol University
Department of Orthopaedics,
Faculty of Medicine Ramathibodi Hospital,
Mahidol University
Eligibility
Sex/Gender
All
Age
50 Years to 77 Years
Inclusion criteria
Inclusion criteria: the subjects had knee pain and radiographic osteophytes appear at the margins of the joint with at least one of the following features 1 age more than or equal 50 years 2 morning stiffness less than 30 minutes and 3 crepitus on motion
Exclusion criteria
Exclusion criteria: history of peptic ulcer steroid or hyaluronic intra articular injection within 3 months unable to walk hypersensitive to NSAIDs or concomitant use of anti inflammatory or analgesic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Western Ontario McMaster Osteoarthritis (WOMAC) score four weeks and sixteen weeks Questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC’s pain, stiffness, function subscales and 36 Question Short Form Health Survey (SF-36) four weeks and sixteen weeks Questionnaire | — |
Countries
Thailand
Contacts
Public ContactAssoc. Prof. Supeenun Unchern
Department of Pharmacology, Faculty of Science, Mahidol University
Outcome results
None listed