Metoclopramide, versus it’s combination with dexamethasone in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a double-blind randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20140128001

Enrollment

Unknown

Registered

2014-01-28

Start date

2012-01-30

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gallstones Gallbladder polyp Metoclopramide Dexamethasone Postoperative nausea and vomiting (PONV) Laparoscopic cholecystectomy

Interventions

Active Comparator Drug,Active Comparator Drug

IV Metoclopramide 10 mg and Dexamethasone 8 mg, IV Metoclopramide 10 mg

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients with American Society of Anaesthesiologists physical status classification (ASA) 1-2. 2. Patients requiring elective laparoscopic cholecystectomy.

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Breast feeding 3. History of motion sickness 4. Nausea/vomiting use of antiemetics within 24 hrs prior to surgery 5. Insulin-dependent DM 6. Allergy to any protocol medication 7. Conversion to open cholecystectomy 8. Development of intraoperative complication 9. Contraindication for dexamethasone: tuberculosis, herpes simplex virus of ophthalmic 10. Contraindication for metoclopramide: epilepsy, pheochromocytoma, antipsychotic (haloperidol, chlorpromazine) treated patients

Design outcomes

Primary

Measure	Time frame
Postoperative nausea and vomiting Postoperative period after laparoscopic cholecystectomy Incidence	—

Secondary

Measure	Time frame
Postoperative pain Postoperative period after laparoscopic cholecystectomy Pain score	—

Contacts

Public ContactWasana Ko-iam

Chiang Mai University

waskoiam@med.cmu.ac.th+66+88+2525787

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Metoclopramide&#44; versus it’s combination with dexamethasone in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a double&#45;blind randomized controlled trial