Effectiveness of Hevea Brasiliensis extract improving periorbital fine wrinkle, spilt face Randomized double-blind Placebo Control Trial

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20140125001

Enrollment

Registered

2014-01-25

Start date

2014-03-17

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effectiveness of Hevea Brasiliensis extract improving periorbital fine wrinkle Fine wrinkle Periorbital wrinkle Hevea Brasiliensis extract

Interventions

apply 5 drops of Hevea Brasiliensis extract at half face

Experimental Drug

Hevea Brasiliensis extract

Eligibility

Sex/Gender

All

Age

25 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.healthy male or female age between 25-60 years old 2.fine wrinkle grade 1-3 3.volunteer should accept the agreement of research before study 4.volunteer should sign the inform consent before study

Exclusion criteria

Exclusion criteria: 1.history of hyperallergic reaction, allergy to rubber 2.history of eczema or chronic skin condition such as psoriasis in prior 6 months 3.history of undrlying disease that involve the elasticity of skin 4.history of rejuvination surgery 5.pregnancy 6.history of frequent smoking or alcohol drinking

Design outcomes

Primary

Measure	Time frame
wrinkle severity scale by VISIA at 3month 3 month wrinkle severity scale by VISIA	—

Secondary

Measure	Time frame
wrinkle severity scale by VISIA at 1,6 month 1,6 month wrinkle severity scale by VISIA	—

Countries

Thailand

Contacts

Public ContactJade Wititsuwannakul

jademdcu@yahoo.com02-2564253

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Effectiveness of Hevea Brasiliensis extract improving periorbital fine wrinkle&#44; spilt face Randomized double&#45;blind Placebo Control Trial