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Magnesium Sulfate Reduces Incidence of Atrial Fibrillation after Coronary Arterial Bypass Surgery: What is the Proper Dose? A Randomized Control Trial

Magnesium Sulfate Reduces Incidence of Atrial Fibrillation after Coronary Arterial Bypass Surgery: What is the Proper Dose? A Randomized Control Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20140122001
Enrollment
Unknown
Registered
2014-01-22
Start date
2008-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation Magnesium sulfate atrial fibrillation CABG cardiac surgery

Interventions

MgSO4 was re&#45
installed to new bottle without any label&#44
so&#44
all study personnel and participants were blinded to treatment assignment for the duration of the study. bottle 1 is low dose of Magnesium sulfate 5 gm/25ml per bottle. The drug was mixed with norma
all study personnel and participants were blinded to treatment assignment for the duration of the study. bottle 2 is high dose of Magnesium sulfate 10 gm/25ml per bottle. The drug was mixed with nor
Active Comparator Drug,Active Comparator Drug
Bottle 1,Bottle 2

Sponsors

No
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: coronary arterial disease that required elective coronary arterial bypass grafting operation without any exclusion criteria between August 2008 and Febuary 2012

Exclusion criteria

Exclusion criteria: Sick sinus syndrome 2nd or 3rd degree atrioventricular block history of AF any other surgical procedure during the current admissio Q-wave myocardial infarction in the preceding 6 weeks Ongoing treatment with amiodarone, digoxin or warfarin Permanent pacemaker implantation Valvular regurgitation Renal failure (serum creatinine > 2.0) Preoperative serum magnesium level > 4.0 mEq/dl

Design outcomes

Primary

MeasureTime frame
incidence of atrial fibrillation before discharge ECG monitoring

Secondary

MeasureTime frame
length of stay until discharge days of postoperative admission,length of ICU stay until discharge from ICU days of postoperative ICU stay,Cost of medical care until discharge total cost of hospital stay during same admission

Contacts

Public ContactNoppon Taksaudom

Chiang Mai University

drnoppon@hotmail.com+66+53+945537

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026