immunogenicity booster rabies vaccination
Conditions
Interventions
After receipt of incomplete Thai Red Cross intradermal rabies vaccination regimen for 6 months,
0.1 mL of cell-
culture rabies vaccine inject intradermally at one site (deltoid area) on day 0,After receipt of incomplete Thai Red Cross intradermal rabies vaccination regimen for 6 months,
culture rabies vaccine inject intradermally at one site (deltoid area) on day 0 and 3,After receipt of incomplete Thai Red Cross intradermal rabies vaccination regimen for 6 months,
culture rabies vaccine inject subcutaneously at one site (deltoid area) on day 0
Experimental Biological/Vaccine,Active Comparator Biological/Vaccine,Experimental Biological/Vaccine
One intradermal booster injection on day 0,conventional intradermal booster injection on day 0 and 3,One subcutaneous booster injection on day 0
Sponsors
Queen Saovabha Memorial Institute
Queen Saovabha Memorial Institute
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Healthy, age 18-60 years old Willing to participate in this study can follow the protocol study
Exclusion criteria
Exclusion criteria: - previous history of rabies immunization - immunocompromised conditions - Allergy to rabies vaccine or its components - Pregnant - Receiving blood products within 3 months - Acute illness (Temporary exclusion criteria)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rabies Neutralizing Antibody Titers Day 192, 201, 277 Rapid Fluorescent Focus Inhibition Test | — |
Secondary
| Measure | Time frame |
|---|---|
| safety of booster rabies vaccination Through the study local and systemic adverse reactions | — |
Countries
Thailand
Contacts
Public ContactSuda Sibunruang
Queen Saovabha Memorial Institute
Outcome results
None listed