allergy to serratiopeptidase and NSAID peptic ulcer serratiopeptidase,
Conditions
Interventions
Serratiopeptidase 5 mg. before surgery and after surgery 3 times a day for 5 days,Ibuprofen 400 mg. before surgery and after surgery 3 times a day for 5 days
Active Comparator Drug,Active Comparator Drug
serratiopeptidase,ibuprofen
Sponsors
Faculty of Dentistry, Khon Kaen University
Oral and Maxillofacial Surgery Department
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: - pt with 18-40 years old -ASA class I ( American Society of Anesthesiologist physical status classification I) -patient with manidbular third molar Pederson scale moderate and difficult -mandibular third molar with no pathology
Exclusion criteria
Exclusion criteria: - patient with medical conditions included : peptic ulceration, GI hemorrhage, pegnancy, immunosuppresive drug recieved, recieved oral contraceptive, used antibiotic before mandibular third molar surgery, infected in the operation site, allergy of NSAID and serratiopeptidase, radiation therapy, trismus, smoking and alcoholic patient and patient that had surgical removal third molar before.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cheek swelling pre-operative,day 1,3,7 after surgery distances from tragus to the outer corner of the mouth,pain pre-operative, day 1 : 3,6 hours ater surgery and 1hour before recieve drug , day 3 and 7 after surg visual analog scale,trismus pre-operative,day 1,3,7 after surgery the distances between the upper and lower central incisal edges | — |
Secondary
| Measure | Time frame |
|---|---|
| The adverse effect of drugs interventions the numbers of patients | — |
Countries
Thailand
Contacts
Public ContactSupaporn Kongsomboon
Faculty of Dentistry
Outcome results
None listed