Type 2 diabetes Insulin,
Conditions
Interventions
comparison between SU withdrawal and SU continuation,withdraw sulfonylurea
Active Comparator Drug,Placebo Comparator Drug
sulfonylurea continuation,SU withdrawal
Sponsors
Routine to Research Unit Siriraj Hospital (R2R)
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: Type 2 diabetic patients, 30 to 75 year-old, who were treated with insulin in combination with SU, were enrolled in the study. All the subjects have been treated with insulin for at least 3 years and SU at half of the maximum doses or higher. All subjects had hemoglobin A1C levels (HbA1c) of less than 8.5% and stable insulin dosage (less than 10% adjustment) for at least three months prior to the enrollment. Patients who received metformin were included in the study
Exclusion criteria
Exclusion criteria: Patients were excluded if they had other types of diabetes, received treatment with a combination of SU and once-daily insulin, or received thiazolidinediones or other medications which interfered with glucose or lipid metabolism. Other exclusion criteria included history of clinically significant heart disease (New York Heart Association Functional Classification greater than class II or abnormalities other than non-specific ST-T wave changes on the EKG), peripheral vascular disease, pulmonary disease, impaired renal function, poor blood pressure control, electrolyte abnormalities, and neuromuscular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycemic control 8 wk HbA1c/ Blood sugar | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin secretion 2 week Oral glucose tolerance test | — |
Countries
Thailand
Contacts
Public ContactWeerachai Srivanichakorn
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed