Effectiveness of 3% boric acid in 70% alcohol versus 1% clotrimazole solution in otomycosis patients: a randomized controlled trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20120000003

Enrollment

120

Registered

2012-03-30

Start date

2012-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

compare effectiveness of boric acid versus clotrimazole solution otomycosis 3% boric acid clotrimazole solution

Interventions

antifungal solution,acidifying agent that can also be an antifungal agent

Experimental Drug,Active Comparator Drug

1% clotrimazole solution,3% Boric acid

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Symptomatic otomycosis, age more than 18 year. - Microscopic finding revealed fungus - KOH smear positive for fungus

Exclusion criteria

Exclusion criteria: - Pregnancy - Tympanic membrane perforation and post mastoid surgery - Co-infection e.g. severe otitis externa, sinusitis and tonsillitis which are needed other medications - Previous using topical antibiotic / steroid within 2weeks. - During usage of systemic antifungal drug - Allergic to 3% boric acid in isopropyl alcohol or 1% clotrimazole solution. - Those who can not come to follow up after one week of the treatment

Design outcomes

Primary

Measure	Time frame
Treatment outcome 1wk after treatment otolaryngologist's microscopic finding	—

Secondary

Measure	Time frame
adverse effects after giving treatment questionaire	—

Countries

Thaoland

Contacts

Public ContactSarisa Romsaithong

unaffiliate

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026