Outcomes after Chronic Blood Transfusion in Thalassemia with Pulmonary Arterial Hypertension

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20110000019

Enrollment

Registered

2011-10-14

Start date

2011-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thalassemia patients Thalassemia pulmonary arterial hypertension blood transfusion

Interventions

the patients receive packed red cells transfusion every 2&#45

4 weeks in one year. ,PRC transfusion less than every 4 weeks in one year

Experimental Other,Active Comparator Other

Chronic blood transfusion,occasionally transfusion

Eligibility

Sex/Gender

All

Age

15 Years to 70 Years

Inclusion criteria

Inclusion criteria: Thalassemia intermedia: E/β-thalassaemia Pulmonary arterial hypertension (PAP > 35 mmHg by ECHO) Hemoglobin level 6.0 – 9.9 g/dl. Serum ferritin level less than 2,000 ug/dl. Capable of follow up and Informed concent

Exclusion criteria

Exclusion criteria: clinical evidence of other secondary causes of pulmonary arterial hypertension, eg. HIV infection, collagen vascular diseases, chronic obstructive airway disease, acquired heart disease associated with pulmonary venous hypertension eg. mitral valve disease, congenital heart disease and hyperthyroidism. - Poor compliance of chelation therapy. - The patients who had alloantibody to red blood cells.

Design outcomes

Primary

Measure	Time frame
Pulmonary artery pressure difference (PASP) initial, 6 months, 12 months Echocardiography: The differences of PASP between before and the end of study	—

Secondary

Measure	Time frame
Six minutes walk test (6MWT) differences initial, 6 months, 12 months Six minutes walk test (6MWT)	—

Countries

Thailand

Contacts

Public ContactNonlawan Chueamuangphan

Faculty of Medicine, CMU

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026