Bronchial asthma
Conditions
Interventions
Study setting: Emergency Treatment Unit at National Hospital, Galle.
Randomization:
a. Method of randomization : Block randomisation according to gender.
b. Unit of randomization: Individual
c. Meth
sequentially numbered, opaque, sealed envelopes
Intervention: Both groups will receive back-back nebulization with salbutamol, which is the standard therapy outlined in the GINA guidelines. Thereaft
2.5 ml of isotonic solution
if failing to respond will be moved to intravenous magnesium sulphate.
Control: Intravenous magnesium sulphate 40mg/kg over 20 minutes, when not responding to back-back nebulization with salbutamol,
Sponsors
Faculty of Medicine, University of Ruhuna
Eligibility
Inclusion criteria
Inclusion criteria: Both male and female The children aged between 2-12 years Pediatrician diagnosed Acute Severe Asthma; PRAM ( Pediatric Respiratory Assessment Measures) score between 8-12
Exclusion criteria
Exclusion criteria: The children admitted with mild- moderate asthma with PRAM score less than 8 The children with heart failure The children with chronic lung disease other than asthma The children who have diagnosed structural lung diseases such as Congenital cystic adenomatous malformation, congenital lobar emphysema, diaphragmatic hernia etc The children who have medical conditions that mimic respiratory distress eg; metabolic diseases, laryngo tracheomalacia etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PRAM score (Pediatric Respiratory Assessment Measures) [Fifteen minutes after the completion of the intervention, either with nebulised or intravenous magnesium sulphate ] | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects of nebulised magnesium - Hypotension Tachycardia Diminished tendon reflexes [15-20 minutes after the initial intervention with intravenous or nebulised magnesium sulphate Those who failed to improve with nebulised MgSO4 will again be assessed 15-20 minutes after the intravenous magnesium sulphate . ] | — |
Countries
Sri Lanka
Contacts
Public ContactPushpika Prabashini Jayawardana
Associate professor
Outcome results
None listed