Acute oleander poisoning
Conditions
Interventions
Study Settings - Teaching Hospital Batticaloa and Teaching Hospital Kurunegala
Randomization: Patients presenting with acute oleander poisoning within 6 hours of ingestion, who meet the inclusion/exc
Sponsors
Research Council - Univeristy of Sri Jayewardenepura
Eligibility
Inclusion criteria
Inclusion criteria: 1. The patient should be admitted to the study hospital within 6 hours of oleander ingestion 2. Patients should have signs and symptoms suggestive of systemic oleander poisoning: Presence of any of the following signs within first 2 hours of admiss ion would be considered as evidence of systemic intoxication. - Bradycardia with a heart rate of less than 60 beats /minute - Presence of reverse tick sign of digoxin effect in ECG - Systolic blood pressure less than 80 Hg mm 3. Symptoms such as nausea, vomiting, abdominal pain, diarrheoa, xanthopsia
Exclusion criteria
Exclusion criteria: 1. Patients below 16 years of age 2. Pregnant women 3. Patients with a history of ischemic or valvular heart disease 4. Patient with a history of significant cardiac diseases 5. Patients with a history of co-poisoning with other pharmacological agents which affect heart rate, such as calcium-channel blockers, beta-blockers, amiodarone and other antiarrhythmic drugs 6. Patients who were on medication which affect heart rate and rhythm, such as calcium-channel blockers, beta-blockers, amiodarone and other antiarrhythmic drugs. 7. Patients who were already given oral magnesium sulphate following acute oleander poisoning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Case fatality rate - by observing number of deaths [At any given point of the hospital stay of the patient (at point of patient death)] Incidence of development of brady-arrhythmias (According to ECGs) [Within the first 24 hours of admission] Percentage of deaths [At any given point of the hospital stay of the patient (at point of patient death)] Percentage of deaths [At any given point of the hospital stay of the patient (at point of patient death)] Percentage of deaths [At any given point of the hospital stay of the patient (at point of patient death)] | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of symptomatic brady-arrhythmias (1st degree/ second degree/ third degree Atrio-ventricular blocks) - using 4 hourly ECGs for first 24 hours [With in the first 24 hours of admission - at the point of developing the arrhythmia] Incidence of hyperkalemia and hypokalemia - by collecting blood on admission and every 6 hourly for first 24 hours [ With in the first 24 hours of admission - at the point of development of hyperkalemia and/or hypokalemia] Incidence of temporary cardiac pacing [ With in the first 24 hours of admission at the point when patient is subjected to temporary cardiac pacing] Duration of hospital stay [ At discharge] Incidence of tachy-arrhythmias - using 4 hourly ECGs for first 24 hours [ With in the first 24 hours of admission - at the point of development of the arrhythmia ] Reversal of brady-arrhythmias - using 4 hourly ECGs for first 24 hours [With in the first 24 hours of admission - at the point the arrhythmia is developed ] | — |
Countries
Sri Lanka
Contacts
Public ContactDr. W.M.A.B.W. Eriyawa
Lecturer in Pharmacology
Outcome results
None listed