Leptospirosis pulmonary haemorrhage
Conditions
Interventions
Study will be conducted at Colombo South Teaching Hospital, National Hospital of Sri Lanka Teaching Hospital Karapitiya and Colombo North Teaching Hospital* (*added on 14.08.2026)
A balanced design w
IV Ceftriaxone 1g BD for 7 days, Renal replacement therapy for acute kidney injury, respiratory support for pulmonary haemorrhage and blood product transfusions for coagulopathy will be continued as p
Sponsors
University of Sri Jayewardenepura
Eligibility
Inclusion criteria
Inclusion criteria: - Suspected leptospirosis patients with evidence of leptospirosis pulmonary haemorrhage syndrome (defined as the presence of one or more of haemoptysis, arterial hypoxemia, haemoglobin reduction >10% from baseline with radiographic evidence of pulmonary haemorrhage) - Males and females
Exclusion criteria
Exclusion criteria: - Patients <18 years of age - Pregnancy - Patients on long-term glucocorticoids - Patients with active co-infections on recruitment (eg: dengue, sepsis, tuberculosis, systemic fungal infections) - Patients with underlying bleeding disorders - Patients with pre-existing lung diseases interfering with chest radiograph interpretation (eg: interstitial lung disease, bronchiectasis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All cause in-hospital mortality [At hospital discharge or death] | — |
Secondary
| Measure | Time frame |
|---|---|
| - Development of hospital-acquired infections Criteria for hospital-acquired infections: -Ventilator-associated pneumonia defined as having new or progressive infiltrates in chest radiograph with clinical/laboratory features suggestive of infection (leucocytosis, elevated C reactive protein, fever) in a patient on mechanical ventilator - Urosepsis: Clinical/laboratory features of new infection with positive urine culture or suggestive urinalysis - Catheter-related blood stream infections: Clinical/laboratory features of new infection with positive catheter and blood culture positivity from the same micro-organism - Cannula-site infection: Clinically apparent cannula site infection (local redness, warmth in a site of cannula placement [At hospital discharge or death] Duration of respiratory support (length of mechanical ventilation, duration of HFNO/NIV therapy) [ At hospital discharge or death] Duration of ICU stay [ At hospital discharge or death] Duration of hospital stay [ At hospital discharge or death] Side effects of steroid therapy (hyperglycaemia, high blood pressure, hyponatraemia, peptic ulcer disease) [ At hospital discharge or death] | — |
Countries
Sri Lanka
Contacts
Public ContactDr Nilanka Perera
Senior Lecturer
Outcome results
None listed