Snakebite associated thrombotic microangiopathy
Conditions
Interventions
Study setting: At five hospitals
NHSL -Colombo, TH Peradeniya, NHSL- Kandy, TH Anuradhapura, and
TH Kurunegala.
Study population: All patients who have been bitten by a RV (Russell's Viper) or HNV (Humped No
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. All males and females 2. All patients with age equal to more than 18 years 2. Patients diagnosed with TMA with or without AKI following RV or HNV bite 3. Patients directly admitted or transferred to the hospital within 5 days of the snakebite Criteria used for diagnosis of TMA: TMA is confirmed by the presence of microangiopathic haemolytic anaemia (MAHA) with > 1.0% schistocytes in peripheral blood film examination with absolute thrombocytopenia 25% reduced platelet count from baseline, with or without AKI. At each study site, the local hematologists will be provided with a protocol to identify TMA by recognizing and calculating schistocytes in the peripheral blood
Exclusion criteria
Exclusion criteria: 1. Patients having known allergy to drug prodcuts 2. Pregnancy 3. Patients having allergic reactions to blood products 4. Patients with pre-existing chronic kidney disease with an eGFR <30 ml/min/1.73m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| "Survival" defined as whether the patient is alive or deceased at the three-month mark. Tool used: Medical records or direct follow up [At the time of discharge and 3 months after discharge from the hospital ] "Dialysis dependency" defined as whether the patient requires ongoing dialysis treatments for kidney function [ At the time of discharge and 3 months after discharge from the hospital ] Glomerular filtration rate (eGFR) <30 ml/min/1.73m2 [An eGFR <30 ml/min/1.73m2 signifies severe kidney dysfunction] [ At the time of discharge and 3 months after discharge from the hospital ] | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of blood transfusions [At the time of discharge from the hospital ] Number of dialysis received [ At the time of discharge from the hospital ] Duration of the hospital stay [ At the time of discharge from the hospital ] | — |
Countries
Sri Lanka
Contacts
Public ContactProfessor Eranga Wijewickrama
Professor
Outcome results
None listed