Assessment of prevalence and characterization of osteoarthritis in four Gravets and Gangawata Korale in the Kandy district and a randomized control trial to assess the effectivity of embolization of genicular artery vs standard care to relieve pain in Kellgren-Lawrnce grade 3 & 4 osteoarthritis among patients attending the rheumatology clinic at Teaching Hospital Peradeniya

Assessment of the prevalence and characterization of osteoarthritis in Kandy four Gravets and Gangawata Korale in the Kandy district and to assess the outcome of Genicular artery embolization in grade 3 and 4 knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

SLCTR

Registry ID

SLCTR/2024/001

Enrollment

Unknown

Registered

2024-02-01

Start date

2024-02-02

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

Study setting: This will be a single-centre study that will be carried out at the Rheumatology clinic, radiology unit and the medical ward at Teaching Hospital Peradeniya and in the research laborator

Eligibility

Inclusion criteria

Inclusion criteria: • Males and females with an age above 30 years • Kelgren-Lawrence (KL) radiographic grading system- grade 3 and 4 knee osteoarthritis • Primary knee OA • Knee pain (>6 on visual analog scale) on at least half of the days in the preceding month at the time of inclusion • Registered patient in rheumatology clinic with at least 6 months of standard medical treatments

Exclusion criteria

Exclusion criteria: • Individual without the mental capacity to consent • Pregnant or lactating individuals • Secondary osteoarthritis (due to inflammatory arthritis) • Contraindication for angiography (ex: coagulopathy, renal insufficiency, contrast allergy) • Previous surgical treatments for knee OA (eg: high tibial osteotomy) excluding knee arthroscopy. • Musculoskeletal comorbidity (e.g: Rheumatoid arthritis or gout) potentially masking the effect of GAE.

Design outcomes

Primary

Measure	Time frame
Improvement in pain as described by the Visual Analog Scale (VAS) [ Baseline, 1 month, 3 months, 6 months and 1 year]	—

Secondary

Measure	Time frame
Western Ontario and McMaster Universities Arthritis Index (WOMAC) functional status assessment. This is used in the evaluation of Hip and Knee Osteoarthritis. It is a questionnaire consisting of 24 items divided into 3 subscales: pain, stiffness and physical function of the subject. [Baseline, 1 month, 3 months, 6 months and 1 year] Muscle strength as measured by the Medical Research Council (MRC) scale of Quadriceps and Hamstring muscle. [Baseline, 1 month, 3 months, 6 months and 1 year] Joint range-of-motion as assessed by the goniometer around the knee. [Baseline, 1 month, 3 months, 6 months and 1 year] Quality of life as measured by the Short form health survey (SF-36) questionnaire [Baseline, 1 month, 3 months, 6 months and 1 year]	—

Measure

Time frame

Western Ontario and McMaster Universities Arthritis Index (WOMAC) functional status assessment. This is used in the evaluation of Hip and Knee Osteoarthritis. It is a questionnaire consisting of 24 items divided into 3 subscales: pain, stiffness and physical function of the subject. [Baseline, 1 month, 3 months, 6 months and 1 year] Muscle strength as measured by the Medical Research Council (MRC) scale of Quadriceps and Hamstring muscle. [Baseline, 1 month, 3 months, 6 months and 1 year] Joint range-of-motion as assessed by the goniometer around the knee. [Baseline, 1 month, 3 months, 6 months and 1 year] Quality of life as measured by the Short form health survey (SF-36) questionnaire [Baseline, 1 month, 3 months, 6 months and 1 year]

—

Contacts

Public ContactH. K. Rumesh Priyadarshana

Physiotherapist

rumeshphysio@gmail.com0812244835

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Sep 19, 2026