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A clinical trial study to compare treatment options, smell training with essential oils, application of steroid nose drops, application of both the steroid nose drops and smell training and watchful waiting for reduced and altered smell after Covid 19 infection in a tertiary care hospital, Sri Lanka

Comparison of olfactory training, topical corticosteroids and combination therapy for the treatment of post COVID-19 olfactory dysfunction in a tertiary care centre, Sri Lanka; Randomized Controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
SLCTR
Registry ID
SLCTR/2023/008
Enrollment
Unknown
Registered
2023-04-17
Start date
2023-05-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Covid-19 Olfactory dysfunction

Interventions

1. Setting - ENT clinic of Colombo South Teaching Hospital of Sri lanka 2. Randomization a. Method of randomization - Simple randomization 23 each for four groups b. Unit of randomization - Patients
citronella, rose, cloves, and eucalyptus twice a day for three months II. Nasal steroids: Two drops of Betamethasone (Probeta) 0.1% nasal drop twice daily for 3 months III. Combination of both the ab

Sponsors

Colombo South Teaching Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: >18 years both males and females PCR confirmed COVID 19 patients Has anosmia or hyposmia as symptom following COVID 19 infection confirmed by Quick smell identification test Symptoms persisted for at least more than one month upto 3 months following confirmation of COVID 19

Exclusion criteria

Exclusion criteria: Previous nasal pathologies including sinonasal tumours, chronic rhinosinusitits, allergic rhinitis, pre-existing anosmia or hyposmia Patients with history of allergy to steroids and patients with past history of anaphylaxis Patients who are already on any kind of systemic or topical steroid Pregnant patients Patients with psychiatric disorders, intellectual disabilities and ambulatory disability Patients treated in ICU Clinical history and rhinological examination will be performed at the ENT clinic to exclude patients with other structural rhinological conditions

Design outcomes

Primary

MeasureTime frame
Quick smell identification test (strip test to identify smell dysfunction which tests 3 different odours) 3 out of 3 score in the QSIT smell identification test [Prior to interventions and 3 months after interventions]

Secondary

MeasureTime frame
None []

Countries

Sri Lanka

Contacts

Public ContactDr. A S R De Alwis

Acting consultant in otorhinolaryngology

2shashini@gmail.com0776415041

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026