Parkinson's disease and Epilepsy
Conditions
Interventions
Protocol will include every other week physical (onsite) guided sessions and twice a week online guided sessions conducted by the meditation trainer throughout the period of 8 weeks of intervention.
Sponsors
World Bank, AHEAD 81 grant
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for Parkinson’s disease group 1) Diagnosis of PD according to Movement Disorder Society clinical diagnostic criteria for Parkinson Disease 2) Patients in Hoehn and Yahr stages I–III 3) Optimally treated with PD medication and unlikely to require anti-PD medication adjustments in the next one month 4) Stable dose of all medications for 30 days prior to inclusion 5) Lack of cognitive dysfunction as evidenced by the Montreal Cognitive Assessment Test (MoCA) (score greater than or equal to 26) 6) No known unstable or life-threatening concomitant disease 7) No previous meditation training and or regular practice 8) Commitment to attend meditation training sessions both onsite and online and to perform the prescribed daily homework of meditation. Inclusion criteria for Epilepsy group 1) Patients aged 18 years or older 2) Having a clinical diagnosis of medication-resistant epilepsy 3) Seizure frequency of 4 or more seizures per month 4) On a stable antiepileptic drug regimen for the prior ?30 days 5) No history of status epilepticus within the previous 6 months 6) Not pregnant or planning pregnancy 7) Able to maintain a seizure diary independently 8) No known unstable or life-threatening concomitant disease 9) No previous meditation training or regular practice 10) Commitment to attend meditation training sessions both onsite and online and to perform the prescribed daily homework of meditation
Exclusion criteria
Exclusion criteria: Exclusion criteria for Parkinson disease group 1) Usage of neuroleptics or other drugs that induce parkinsonism within 60 days prior to inclusion 2) Patients with psychotic symptoms 3) Atypical parkinsonian syndromes Exclusion criteria for Epilepsy group 1.) Patients with coexisting psychiatric diagnosis 2.) Patients with intellectual impairment 3.) Alcohol or substance dependence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In Parkinson's disease group Change in mean motor scores (using SPES/SCOPA – Motor scale) and non motor scores (using SENS-PD scale) between groups [Baseline, 4 weeks of commencing intervention, 8 weeks of intervention ] In epilepsy group Effects on seizures (frequency and duration) using a self-reported seizure diary [Baseline, 4 weeks of commencing intervention, 8 weeks of intervention] | — |
Secondary
| Measure | Time frame |
|---|---|
| In Parkinson's disease group 1. Change in mean scores on cognition (using SCOPA-COG scale) 2. Change in mean scores on quality of life (using questionnaire, PDQ-39) 3. Change in mean scores of gait assessment using TUG (time up and go) test. between both groups. [Baseline, 4 weeks of commencing intervention, 8 weeks of intervention] In epilepsy group 1. Percentage distribution of EEG wave form frequencies in different scalp regions would be compared between the 2 groups 2. Change in mean scores in cognition using RBANS questionnaire between groups. 3. Change in mean scores in quality of life using QUOLIE-31 questionnaire between groups. [Baseline, 4 weeks of commencing intervention, 8 weeks of intervention] | — |
Countries
Sri Lanka
Contacts
Public ContactKumarangie Vithanage
Senior Lecturer and Consultant Neurologist
Outcome results
None listed