Type 2 diabetes mellitus
Conditions
Interventions
Patients are selected from the University medical clinic of the National Hospital of Sri Lanka. Patients will be screened for inclusion and exclusion criteria and once informed written consent is obta
Sponsors
Department of Physiology, Faculty of Medicine, University of Colombo
Eligibility
Inclusion criteria
Inclusion criteria: I. Age between 18 and 75 years II. Willingness to participate for a meditation program III. Commitment to adhere to the program for 3 months. IV. Diagnosed with type 2 Diabetes mellitus within the past 3-5 years. V. Patients taking two or less than two anti-diabetic medications VI. HbA1C between 7 and 8% VII. Education level secondary level and above (Grade 8 and above) VIII. Montreal cognitive assessment score more than 26/30
Exclusion criteria
Exclusion criteria: i. Type 1 diabetes ii. Long term meditators/experienced meditators (Long term experienced meditators are defined as those who have been practicing meditation at least for the last three years including those who participate in regular weekly formal meditation sessions and those who regularly self practice meditation six hours per week or more.) iii. Hemoglobinopathy (Patients with Thalassemia/sickle cell disease/sickle-thalassemia, abnormal hemoglobin (HbE,HbS, HbC)) that can interfere with HbA1C monitoring. iv. Renal impairment (Estimated GFR less than 60mL/min/1.73m2) v. Any malignancy vi. Any other chronic disorders (ex. thyroid disease) vii. Patients on steroids, insulin, beta blockers, calcium channel blockers cisapride, domperidone, other anti-arrhythmic medication, antidepressants, antihistamineand sympathomimetic cough preparations26 viii. Alcohol abuse or use of neurotoxic medication ix. History of post traumatic stress disorder, epilepsy, depression or psychosis. x. Diagnosed autonomic dysfunction or peripheral neuropathy. xi. Presence of acute illness and severe systemic disease xii. Angina pectoris xiii. Congestive heart failure NYHA Class III-IV xiv. Diagnosed cardiac arrhythmia xv. Myocardial infarction or invasive cardiovascular procedure within the past six months. xvi. Stroke in last 6 months xvii. Patients with chronic diarrhoea xviii. Patients who are unable to attend weekly meditation sessions xix. Patients not consenting for meditation xx. Montreal cognitive assessment score of less than 26/30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycemic control FBS, HbA1C, Fructosamine [Before intervention and 12 weeks after intervention] | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid profile. Blood pressure. Insulin resistance Autonomic functions assessed by cardiac Autonomic reflex testing (Ewing method) Gut transit time(orocaecal transit time using Hydrogen breath analysis) 24-hour urinary cortisol [Before intervention and 12 weeks after intervention] | — |
Countries
Sri Lanka
Contacts
Public ContactDr. K.P. Chamila Dalpatadu
Senior Lecturer, Department of Physiology, Faculty of Medicine, University of Colombo.
Outcome results
None listed