Post-exposure prophylaxis for COVID-19
Conditions
Interventions
This will be a placebo-controlled, randomized, clinical trial.
The study will be carried out among all eligible persons meeting the inclusion/exclusion criteria directed to be quarantined in quarant
Sponsors
Department of Medicine, Faculty of Medicine, University of Kelaniya
State Pharmaceuticals Manufacturing Corporation (SPMC), Sri Lanka
Eligibility
Inclusion criteria
Inclusion criteria: 1. All consenting male and female adult Naval personnel (18-59.9 years of age) 2. Exposure to a patient with confirmed COVID-19 infection (rRT-PCR positive for SARS-CoV-2 virus) 3. The exposure should be for >30 mins within 2 meters of the infected individual and should be within ONE WEEK at the time of inclusion in the study 4. Recruited within 48 hours of admission to these centers 5. Willing to take study drug as directed for 5 days.
Exclusion criteria
Exclusion criteria: 1. Pregnant females 2. Suspected or confirmed to have COVID-19 infection (i.e Navy personnel having positive rRT-PCR test for COVID-19 or presence of fever with cough, shortness of breath, sore throat, anosmia or diarrhoea at the time of recruitment) 3. Presence of pre-existing cardiovascular disease including being on medication for ischaemic heart disease 4. Presence of contraindication to the use of HCQ (on other medications predisposing to long QT or presence of long QT on baseline ECG) 5. Prior diagnosis of retinopathy, G6PD, malignancy or advanced kidney disease 6. Known sensitivity or allergy to Hydroxychloroquine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of participants symptomatic for COVID-19. (Symptomatic illness will be defined as presence of fever with cough, shortness of breath, sore throat, anosmia or diarrhoea) [Time frame: from the time of recruitment until the completion of 14 days] Number of participants testing positive for SARS-CoV-2 virus using rRT-PCR [ Time frame: day 14 from the time of recruitment] | — |
Secondary
| Measure | Time frame |
|---|---|
| None [] | — |
Countries
Sri Lanka
Contacts
Public ContactNiriella MA
Professor in Gastroenterology
Outcome results
None listed