Chronic kidney disease of uncertain etiology in Sri Lanka.
Conditions
Interventions
1. Study setting - Nephrology clinic, District General Hospital, Polonnaruwa
2. Randomization - Simple randomization without replacement.
3. There will be four arms of the study. Control group will
Sponsors
Department of Medicine, Faculty of Medicine
Eligibility
Inclusion criteria
Inclusion criteria: • Age 18-60 years • Able to provide informed consent and willing to complete the follow-up visit • Estimated glomerular filtration rate between 30 and 60 ml/min/1.73m2 • Suffering from CKDu (ie other identifiable causes of CKD excluded)
Exclusion criteria
Exclusion criteria: • History of allergy to Zinc or Selenium • Hemodialysis or peritoneal dialysis currently or within six months of recruitment • Renal transplant recipient • Pregnancy • Breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of change in eGFR and change of urine albumin/ creatinine ratio between baseline and final follow-up. eGFR will be calculated from serum creatinine using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. [At the completion of three months.] | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in body mass index, blood pressure and hemoglobin. [At the completion of three months.] | — |
Countries
Sri Lanka
Contacts
Public ContactDr. Prabath K Abeysundara
Senior Registrar in Internal Medicine
Outcome results
None listed