Non-Alcoholic Fatty Liver Disease
Conditions
Interventions
The study will be conducted at the Dietetic and Nutrition Clinic of Durdans hospital, Colombo-03.
Subjects for the treatment and control will be randomly assigned using a random number table.
At th
Sponsors
Durdans Hospital, 3, Alfred place, Colombo 3
Eligibility
Inclusion criteria
Inclusion criteria: Subjects who are diagnosed to have NAFLD by a medical officer or a medical consultant [based on hepatic ultrasonography and elevated levels (>1.5xUpper Limit) of alanine aminotransferase (ALT) concentration] and are referred to a registered Dietician & Nutritionist. Age between 30-55 years
Exclusion criteria
Exclusion criteria: Subjects having other acute or chronic liver diseases of other etiologies (viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, hereditary haemochromatosis, Wilson's disease, drug induced liver injury; cholestasis). Subjects who are pregnant and / or lactating Subjects who have history of malignancy, history of significant alcohol consumption (>14 units/week for men, >7 units/week for females) Subjects who are taking antibiotics, probiotics, vitamin, mineral, antioxidants, omega-3 or any other food supplements preceding enrollment Subjects who are on treatment with vitamin E, statins within 3 months prior to the starting date of the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in levels of Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Gamma Glutamyl Transpeptidase (GGT). [At the baseline of the study and at 8 weeks] | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in weight and BMI. Change in dietary measures (assessed using 24-h dietary recalls and semi quantitative food frequency questionnaire) Change in physical activity ( assessed using Short Form of the International Physical Activity Questionnaire. [At the baseline of the study and at 8 weeks] | — |
Countries
Sri Lanka
Contacts
Public ContactMaheshani Wimalathunga
Dietician and Nutritionist
Outcome results
None listed