The effect of local Platelet Rich Plasma Injection on the Rate of Orthodontically Induced Canine Retraction and Root Resorption in Subject with Bi-Maxillary Protrusion.

The effect of local Platelet rich Plasma Injection on the Rate of Orthodontically Induced Canine Retraction and Root Resorption in Subjects with Bi-Maxillary Protrusion.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

SLCTR

Registry ID

SLCTR/2018/040

Enrollment

Unknown

Registered

2018-12-14

Start date

2018-12-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malocclusion

Interventions

Study setting - Dermo-dento center , a specialist dermatological and dental center in sulimani city. Intervention - • 5ml of Platelet rich plasma will be obtained through double centrifugation of p

Eligibility

Inclusion criteria

Inclusion criteria: 1- Aged between 18 and 26 years. 2- Bimaxillary protrusion 3- Minimum crowding(less than 2mm) or minimum spacing (less than 4 mm). 4- Indication for extraction of upper and lower first premolars. 5- The feasibility of bonding brackets. 6- No previous orthodontic treatment. 7- No systemic diseases. 8- Good oral hygiene. DMFT index (decay, missing, filling), plaque index

Exclusion criteria

Exclusion criteria: 1- Patients with severe tooth displacement (e.g. ectopic canine) 2- Those reporting the use of medications throughout the study.

Design outcomes

Primary

Measure	Time frame
The overall duration of canine retraction. Canine retraction is defined as, the space between the distal surface (connector) of the canine and medial surface of the 2nd premolars (upper and lower) for both the right and left sides before starting retraction(T0) and after 14 days (T1), 30 days (T2)and 60 days(T3) with the use of inLab CAM 15.0 software after scanning the casts with CEREC Omnicam scanner [12 months]	—

Measure

Time frame

The overall duration of canine retraction. Canine retraction is defined as, the space between the distal surface (connector) of the canine and medial surface of the 2nd premolars (upper and lower) for both the right and left sides before starting retraction(T0) and after 14 days (T1), 30 days (T2)and 60 days(T3) with the use of inLab CAM 15.0 software after scanning the casts with CEREC Omnicam scanner [12 months]

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Secondary

Measure	Time frame
1. C-reactive protein (hs-CRP) level. 2. CBC parameters. 3. Levels of aspartate aminotransferase (AST) 4. Alanine aminotransferase (ALT) 5. Gamma glutamyl transferase (GGT) 6. Alkaline phosphatase (ALP) 7. Blood Urea 8. Creatinine 9. Serum Sodium (Na) 10. Serum Potassium (K) 11. Serum Calcium (Ca) 12. Serum Total protein (TP) 13. Albumin (Alb) 14. Bone Density Area. The area distal to maxillary left and right canines will be selected as the target area. Before measuring the bone densities around the teeth, the whole CBCT images will be resliced to obtain new slices that will perpendicular to the longitudinal axes of the teeth by using the “reslice” function. The bone density distal to the canines will be assessed at intermediate level (between the cervical and apical levels). Hounsfield units (HU) of bone tissue will be used in assessing radiographic bone density under identical dental CBCT scan settings; this method can be used to analyze changes in bone density around a tooth position before and after orthodontic treatment (Pauwels et al, 2017). 15. Root resorption will be evaluated by volumetric measurement (Baysal et al, 2012). Volume renderings will be reconstructed, and the volumetric images will be manipulated to display the root surfaces from various orientations. On these 3D images, the canines will be conservatively segmented. After segmentation, teeth will be separated from the other teeth and adjusted for 3D orientations. Incisor edge oriented parallel to the floor. Root will be isolated and color coded. The volume of each root will be calculated using the Mimic software program. The root volume loss will be calculated as the difference between the pre-treatment and post-retraction root volumes. [12 months]	—

Measure

Time frame

1. C-reactive protein (hs-CRP) level. 2. CBC parameters. 3. Levels of aspartate aminotransferase (AST) 4. Alanine aminotransferase (ALT) 5. Gamma glutamyl transferase (GGT) 6. Alkaline phosphatase (ALP) 7. Blood Urea 8. Creatinine 9. Serum Sodium (Na) 10. Serum Potassium (K) 11. Serum Calcium (Ca) 12. Serum Total protein (TP) 13. Albumin (Alb) 14. Bone Density Area. The area distal to maxillary left and right canines will be selected as the target area. Before measuring the bone densities around the teeth, the whole CBCT images will be resliced to obtain new slices that will perpendicular to the longitudinal axes of the teeth by using the “reslice” function. The bone density distal to the canines will be assessed at intermediate level (between the cervical and apical levels). Hounsfield units (HU) of bone tissue will be used in assessing radiographic bone density under identical dental CBCT scan settings; this method can be used to analyze changes in bone density around a tooth position before and after orthodontic treatment (Pauwels et al, 2017). 15. Root resorption will be evaluated by volumetric measurement (Baysal et al, 2012). Volume renderings will be reconstructed, and the volumetric images will be manipulated to display the root surfaces from various orientations. On these 3D images, the canines will be conservatively segmented. After segmentation, teeth will be separated from the other teeth and adjusted for 3D orientations. Incisor edge oriented parallel to the floor. Root will be isolated and color coded. The volume of each root will be calculated using the Mimic software program. The root volume loss will be calculated as the difference between the pre-treatment and post-retraction root volumes. [12 months]

—

Countries

Iraq

Contacts

Public ContactTrefa Mohammed Ali

Sulaimani / iraq

trefa.ali@univsul.edu.iq

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026