Acute-on-Chronic Liver Failure.
Conditions
Interventions
Study setting: The patient with Acute-on-Chronic Liver Failure will be admitted into the Department of Hepatology at Bangabandhu Sheikh Mujib Medical University, Dhaka. Patients will be allocated int
Sponsors
Dr. Md. Nazmul Haque
Eligibility
Inclusion criteria
Inclusion criteria: • Age:>18 years • Sex: both sexes • Bilirubin > 5 mg/dl • Coagulopathy (international normalized ratio > 1.5) • Complicated by clinical ascites and/or encephalopathy within 4 weeks • Patient with previously diagnosed or undiagnosed chronic liver disease • Acute insult caused by reactivation of HBV, HBV Flare, HEV,HAV or any aetiology
Exclusion criteria
Exclusion criteria: • Age <18 years • Decompensated Cirrhosis • Coexistent hepatocellular carcinoma (HCC) • Patients on immune-modulator or cytotoxic/immunosuppressive therapy • Co morbidity like heart failure, any malignancy and uncontrolled diabetic patients . • Any previous known hypersensitivity to G-CSF and EPO • Patients unwilling to take part in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in MELD score (Model for end stage liver disease) [At baseline and 90 days ] Change in CTP (Child-Turcotte-Pugh) score [ At baseline and 90 days] Survival [ At 90 days] | — |
Secondary
| Measure | Time frame |
|---|---|
| None [None] | — |
Countries
Bangladesh
Contacts
Public ContactDr. Md. Nazmul Haque
MD Student
Outcome results
None listed