Leptospirosis
Conditions
Interventions
- Study setting: Medical wards, emergency care unit and intensive care units of the Teaching Hospital,
Karapitiya
- Randomisation: patients will be allocated to two arms using the Block randomiz
Sponsors
Dr Nalaka Herath
Dr Wimalasiri Uluwatta
Eligibility
Inclusion criteria
Inclusion criteria: - Age 15 to 80 , with lung hemorrhages due to leptospirosis. Diagnosis of leptospirosis: Patients with a clinical picture suggestive of leptospirosis and confirmed with PCR, MAT or both) Definition of leptospirosis associated pulmonary hemorrhage: Patient with confirmed leptospirosis presenting with haemoptysis, arterial hypoxemia (Acute Lung Score 10% from the previous value), or diffused alveolar shadows in the chest radiograph. The above manifestations should not have an alternative explanation.
Exclusion criteria
Exclusion criteria: - Chronic kidney disease Stages iii, iv, v - Chronic hepatitis and liver cirrhosis of any etiology (compensated or decompensated) - Clinically manifested chronic obstructive airway disease, bronchial asthma, lung fibrosis - Pregnant women - Patients aged 80 years - Patients who are haemodynamically unstable for TPE will also be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival [During the hospital stay and at the time of discharge from the hospital ] | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of the ICU stay and hospital stay [During the hospital stay and at the time of discharge from the hospital ] Need of ventilatory support [ During the hospital stay and at the time of discharge from the hospital ] Need of inotrophs to support blood pressure [ During the hospital stay and at the time of discharge from the hospital ] Use of antiarrhythmic agents [ During the hospital stay and at the time of discharge from the hospital ] Use of renal replacement therapy [ During the hospital stay and at the time of discharge from the hospital ] Use of liver failure therapy [ During the hospital stay and at the time of discharge from the hospital ] Incidence of sepsis [ During the hospital stay and at the time of discharge from the hospital ] Incidence of pneumonia [ During the hospital stay and at the time of discharge from the hospital ] Incidence of line infection spontaneous bleeding [ During the hospital stay and at the time of discharge from the hospital ] | — |
Countries
Sri Lanka
Contacts
Public ContactProf Sarath Lekamwasam
Professor of Medicine
Outcome results
None listed