Dengue fever
Conditions
Interventions
The study will be carried out at Teaching Hospital, Karapitiya
Participants meting the inclusion/exclusion criteria will be randomized into the study arms using a computer generated random number ta
Sponsors
Dr. RWK Kodokara Arachchi
Dr Mrs JDVC Lekamwasam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male and female patients aged between 14-70 years 2. Dengue fever confirmed by positive dengue antigen or specific IGM 3. Platelet count <150,000/microlitre
Exclusion criteria
Exclusion criteria: 1. Plasma leak determined by ultrasonography 2. Pregnant or lactating 3. Decompensated cardiac failure as determined by clinical features 4. Ongoing renal or hepatic disease as determined by clinical features and lab investigations 5. BMI >35kg/m2 6. Known allergy to papaya 7. Previous history of bleeding or platelet disorders 8. Active peptic ulcer disease 9. Concurrent anticoagulant therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence and severity of plasma leakage Occurrence of plasma leak will be determined ultrasonically. The severity of leak will be determined by the requirement of crystalloid and colloid boluses and blood transfusions. [Daily until complete recovery Complete recovery will be defined as defervescence and rise of platelet count >75,000/microlitre ] | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of thrombocytopenia (absolute platelet count) [Daily until complete recovery Complete recovery will be defined as defervescence and rise of platelet count >75,000/microlitre ] Derangement of liver transaminases (absolute serum AST and ALT) [Daily until complete recovery Complete recovery will be defined as defervescence and rise of platelet count >75,000/microlitre ] Duration of hospital stay [ ] | — |
Countries
Sri Lanka
Contacts
Public ContactProf. Sarath Lekamwasam
Professor of Medicine
Outcome results
None listed