Nephrotic syndrome
Conditions
Interventions
1. Study Setting – University Renal Clinic-Teaching Hospital, Karapitiya,Sri Lanka
2. Number of Arms - 4
a. Patients with 1st episode of nephrotic syndrome will be allocated into 2 treatment arm
60mg/m2/eod for 28 days
50 mg/m2/eod for 28 days
40mg/m2/eod for 28 days
30mg/m2/eod for 28 days
20mg/m2/eod for 28days
10 mg/m2 eod for 28 days
Relapses will be treated with Prednisolone 60mg/m2 daily until urine is protein free for 3 days
then 60mg/m2/eod for 28 days
30mg/m2</
Sponsors
University Renal Clinic
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients presenting with nephrotic syndrome between 1 yr to 12 yrs of age. 2. 1st episode of nephrotic syndrome, defined as patients with gross proteinuria (+++ or more) with UPcr > 200mg/mmol hypoalbuminemia (albumin>2.5g/dl) and odema. 3. Relapse of nephrotic syndrome, defined as gross proteinuria of +++ or more or UPcr >200mg/mmol for more than 3 days in a child who has been previously diagnosed of having nephrotic syndrome.
Exclusion criteria
Exclusion criteria: 1. Patients who are resistance to prednisolone, defined as Faliure to achieve remission after 28 days of daily prednisolone given at a dose of 60mg/m2/day 2. Remission achieved after more than 28 days of daily prednisolone. 3. Nephroic syndrome secondary to systemic diseases 4. Patients having gross hematuria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Duration of remission – Time Period from the initial remission to the 1st relapse. 2. Relapse rate – Number of relapses per year. 3. Duration to become Steroid dependent or Frequent Relapsing. [Monthly until remission is reached, and then every 2 months for a period of three years] | — |
Secondary
| Measure | Time frame |
|---|---|
| Stunting Obesity Cataract [Height and weight will be measured every month while on treatment and every 3months while in remission and plotted in the centile charts ] | — |
Countries
Sri Lanka
Contacts
Public ContactProfessor U.K. Jayantha
Chair and Professor of Paediatrics
Outcome results
None listed