Pre-diabetes
Conditions
Interventions
Study setting: Galle district, Sri Lanka
Recruitment: Subjects will be recruited from Galle district using the latest Voters’ register after applying the inclusion and exclusion criteria. Participant
Sponsors
University Grants Commission, Sri Lanka
Eligibility
Inclusion criteria
Inclusion criteria: Intervention groups 1. Males and females aged > 20 years 2. Oral Glucose Tolerance Test (OGTT) 2 hrs value: between 140 and 199 mg/dl Reference group 1. Males and females aged > 20 years 2. Oral Glucose Tolerance Test (OGTT) 2 hrs value: < 140 mg/dL
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Diagnosed diabetes mellitus or diagnosed by screening test OGTT 2 hr value: > 200 mg/dL 3. Manifested vascular disease such as ischemic heart disease, peripheral vascular disease or cerebrovascular disease 4. Patients already on drugs to modify the vascular risk factors, Eg: • anti-platelets • anti anginals • statins or lipid lowering drugs • folic acid • anti-inflammatory drugs • anticoagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surrogate markers for the progression of atherosclerosis 1.CIMT (carotid artery intima media thickness) 2.Lipid profile [At baseline, 6 months, 12 months and 18 months after commencement of the intervention] | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. HbA1c 2. Hs CRP (high sensitivity C-reactive protein) 3. ECG 4. ABI (Ankle brachial pressure index) 5. Blood pressure measurement 6. Anthropometric measurements and BMI (body mass index) [At baseline, 6 months, 12 months and 18 months after commencement of the intervention] | — |
Countries
Sri Lanka
Contacts
Public ContactDr. A.T. Isuru Madushika Amarasinghe
Lecturer (Probationary)
Outcome results
None listed