Resistant hypertension
Conditions
Interventions
The study will be carried out at medical clinics of the National Hospital of Sri Lanka. Consenting patients meeting inclusion/exclusion criteria will be randomized into two arms.
Intervention arm
P
Sponsors
National Research Council, Sri Lanka
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 18-75 years 2. Resistant hypertension is defined as casual blood pressure during clinical examination of more than 140/90 mmHg (a mean of the 2nd and 3rd measurements during a single examination, at least 3 min apart) despite treatment with a multidrug combination consisting of a diuretic and ACEI/ARB, centrally acting drug, alpha blocker or calcium channel blocker 3. Blood pressure >140/90mmHg in patients below 60 years and >150/90mmHg if above 60 years
Exclusion criteria
Exclusion criteria: 1. Systolic blood pressure > 220mmHg requiring immediate adjustments to therapy 2. Moderate to severe renal insufficiency (acute or chronic) with glomerular filtration rate of less than 30 ml/min , 3. Active bronchospastic disorders 4. Heart failure class III and IV 5. Severe bradycardia(HR<50bpm) 6. AV block 2 and 3 degrees 7. Women who are lactating or pregnant ( a pregnancy test will be carried out during the initial examination) 8. History of hypersensitivity to any of the drugs under study 9. Current use of beta blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure measured by ABPM (ambulatory blood pressure monitoring) [At baseline and three months ] | — |
Secondary
| Measure | Time frame |
|---|---|
| None [None] | — |
Countries
Sri Lanka
Contacts
Public ContactDr. G.R. Constantine
Consultant Cardiologist and Senior Lecturer in Medicine
Outcome results
None listed