Non-alcoholic fatty liver disease
Conditions
Interventions
The study will be carried out at the Department of Pharmacology Faculty of Medicine University of Ruhuna with ultra sound scanning done at Teaching Hospital Karapitiya.
Consenting participants meetin
Sponsors
Faculty of Medicine
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male and female patients aged 30-65 years 2. Diagnosis of NAFLD stage 1 and 2 by ultrasound scan by a physician and radiologist
Exclusion criteria
Exclusion criteria: 1. Alcoholism.(consumption of any alcohol within the past 6 weeks) 2. Current treatment with hepatotoxic drugs. 3. Hepatitis B infection (positive HBsAg with recent vaccination) 4. Diabetes mellitus, heart failure, ischaemic heart disease 5. Autoimmune disorders. 6. Any type of long term drug treatment for diabetes, dyslipidemia or high blood pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. 30% reduction in insulin resistence (IR) calculated by using HOMA QUICKI and McAuley indices 2. Sustained reduction in Alanine aminotransferase(ALT) defined as 50% or less of the baseline level or 40U/L or less at clinic visits every 4 weeks. [At baseline, then every 4 weeks for a total of 12 weeks. ] | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Grading of NAFLD on ultra sound scan 2. Health related quality of life.(QOL) 3. Anthropometric variables [At baseline, then every 4 weeks for a total of 12 weeks.] | — |
Countries
Sri Lanka
Contacts
Public ContactProf Menik Hettihewa
Professor of Pharmacology
Outcome results
None listed