Effects of vitamin E in the treatment of dengue infection in children

Effects of Vitamin E Supplementation on the clinical outcome of Dengue Fever and Dengue Haemorrhagic Fever in Children

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

SLCTR

Registry ID

SLCTR/2015/012

Enrollment

Unknown

Registered

2015-06-19

Start date

2015-06-19

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dengue Infection

Interventions

Participants will be recruited from Ward 1, Lady Ridgeway Hospital (LRH). Consenting participants meeting inclusion/exclusion criteria will be randomized into two arms. The intervention arm will rec

Eligibility

Inclusion criteria

Inclusion criteria: 1. Admission to the study setting (Ward 1, LRH) within 84 hours of the onset of fever 2. Clinical diagnosis of dengue infection (clinical criteria of the National Guidelines for Management of Dengue, Ministry of Health, Sri Lanka)

Exclusion criteria

Exclusion criteria: 1. Any underlying chronic disease (e.g. cardiac disease, renal disease, hepatic disease and muscular disorders) 2. Children on any long term medication

Design outcomes

Primary

Measure	Time frame
Quantitative outcomes 1.1.Platelet count 1.2.Lowest platelet count 1.3.Haematocrit 1.4.Highest haematocrit 1.5.Duration of fever 1.6.Serum albumin [Quantitative outcomes 1. On admission, day 3 and discharge 2. From time of admission to time of discharge All other outcomes will be assessed on day 1, day 3, day 5 and day 7 of illness] Qualitative outcomes 1.1.Entry into critical phase 1.2.Use of dextran 1.3.Presence of effusions on ultra sound scan 1.4.Need for catheterization [ ]	—

Measure

Time frame

Quantitative outcomes 1.1.Platelet count 1.2.Lowest platelet count 1.3.Haematocrit 1.4.Highest haematocrit 1.5.Duration of fever 1.6.Serum albumin [Quantitative outcomes 1. On admission, day 3 and discharge 2. From time of admission to time of discharge All other outcomes will be assessed on day 1, day 3, day 5 and day 7 of illness] Qualitative outcomes 1.1.Entry into critical phase 1.2.Use of dextran 1.3.Presence of effusions on ultra sound scan 1.4.Need for catheterization [ ]

—

Secondary

Measure	Time frame
None [None ]	—

Countries

Sri Lanka

Contacts

Public ContactProf. V. Pujitha Wickramasinghe

Professor in Paediatrics

pujithaw@yahoo.com+94 11 2688748

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026