Blood sugar control after bypass operation - insulin vs oral medication

A randomized controlled trial to compare insulin and metformin versus metformin and sulphonyluria on the short term outcomes after Coronary Artery bypass graft (CABG) in patients with type 2 diabetes

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

SLCTR

Registry ID

SLCTR/2014/024

Enrollment

330

Registered

2014-10-07

Start date

2014-10-07

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart disease, diabetes

Interventions

Consenting patients will be randomized into two arms using a random number table. Randomization will be done around post operative day three when the patient has achieved satisfactory glycaemic contro

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with type 2 diabetes admitted to Cardio-thoracic units of the National Hospital of Sri Lanka for coronary artery bypass grafting (CABG) 2. Daily insulin requirement of <1IU/kg/day to achieve satisfactory glycaemic control

Exclusion criteria

Exclusion criteria: 1. Patients on insulin prior to admission due to oral hypoglycaemic (OHG) failure 2. Daily insulin requirement following CABG >1IU/kg/day. 3. Serum creatinine > 1.5 mg/dl 4. Unstable cardiac failure 5. Chronic liver disease 6. Patients taking drugs affecting glycaemic control (eg. Steroids) 7. Patients unable to return for follow-up 8. Patients who are unable to understand or cooperate with protocol requirements

Design outcomes

Primary

Measure	Time frame
1. HbA1c 2. FBG 3. PPBG [1. HbA1c will be done at 3 months after discharge 2. FBG and PPBG will be done at one week, one month, two months and three months after discharge ]	—

Secondary

Measure	Time frame
1. Surgical wound infection occurring within 30 days of surgery (at least one of the following: purulent discharge from surgical site or drain, organisms isolated from aseptically obtained wound culture, signs and symptoms of infection such as pain or tenderness, localized swelling, or redness/heat). 2. Acute coronary syndrome: Angina associated with dynamic ECG changes and or raised troponin levels 3. Heart failure 4. Stroke 5. Hypoglycaemia (RBG < 70 mg/dL or 3.9 mmol/L) 6. Weight change (5% weight loss or gain over three months) [Monthly after discharge for 3 months]	—

Measure

Time frame

1. Surgical wound infection occurring within 30 days of surgery (at least one of the following: purulent discharge from surgical site or drain, organisms isolated from aseptically obtained wound culture, signs and symptoms of infection such as pain or tenderness, localized swelling, or redness/heat). 2. Acute coronary syndrome: Angina associated with dynamic ECG changes and or raised troponin levels 3. Heart failure 4. Stroke 5. Hypoglycaemia (RBG < 70 mg/dL or 3.9 mmol/L) 6. Weight change (5% weight loss or gain over three months) [Monthly after discharge for 3 months]

—

Countries

Sri Lanka

Contacts

Public ContactLalana Devi Ranasinghe

Senior Registrar in Endocrinology

lalana.devi@gmail.com

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026