Organophosphate poisoning
Conditions
Interventions
Patients meeting inclusion/exclusion criteria will be randomized into three arms.
The first arm will receive standard therapy alone (no rocuronium)
The second arm will receive rocuronium bolus and
Sponsors
South Asian Clinical Toxicology Research Collaboration
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female 2. Age over 16 years 3. Clinical diagnosis of OP insecticide poisoning 4. Admission to Intensive Care Unit for ventilation 5. Informed consent from family 6. An initial Train-of-Four measurement (Neuromuscular junction function) of > 50% using standard anaesthetic neurophysiology equipment
Exclusion criteria
Exclusion criteria: 1. Failure to obtain informed consent from patient’s family 2. Age 16 years or younger 3. Patients who are pregnant 4. Patients will be removed from the study at their own or their family’s request
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days ventilated [On extubation] | — |
Secondary
| Measure | Time frame |
|---|---|
| Train of four measurement on repetitive nerve stimulation. [Every Ventillated day for a maximum of 5 days] | — |
Countries
Sri Lanka
Contacts
Public ContactProfessor Indika Gawarammana
Principle investigator, Director South Asian Clinical Toxicology Research Collaboration
Outcome results
None listed