Nonalcoholic steatohepatitis
Conditions
Interventions
Consenting participants meeting inclusion/exclusion criteria will be randomized into two arms using the lottery method.
The intervention arm will receive Pentoxyfylline 400mg eight hourly for one yea
Sponsors
Bangabandhu Sheikh Mujib Medical University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Ultrasonographic evidence of fatty liver 2. Nonalcoholic fatty liver disease activity score greater than or equal to 5 on liver histopathology
Exclusion criteria
Exclusion criteria: 1. Significant alcohol intake(more than 20 gm /day) 2. History of taking drugs that may cause fatty liver(i.e.tamoxifen, valproic acid, amiodarone, methotrexate) or history of taking drugs that have shown benefit in previous Nonalcoholic steatohepatitis studies(i.e.vitamin E ,metformin, thiazolidinedione, fibrates) 3. Chronic viral hepatitis(HBV , HCV) 4. Pregnancy 5. Co-morbid conditions(Chronic Obstructive Pulmonary Disease ,Chronic Kidney Disease, Congestive CF, Myocardial infarction) 6. Liver failure 7. Hypothyroidism 8. Patient who fails to give consent for paired biopsy 9. Wilson's disease and Hemochromatosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of nonalcoholic fatty liver disease activity score and fibrosis score after one year treatment [At the end of one year] | — |
Secondary
| Measure | Time frame |
|---|---|
| None [None] | — |
Countries
Bangladesh
Contacts
Public ContactDr. S.K.M. Nazmul Hasan
Resident of Hepatology
Outcome results
None listed