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A study on antibiotic use to prevent infections after miscarriage

Prophylactic use of antibiotic (doxycycline) for incomplete and missed miscarriage, prior to medical and surgical management

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
SLCTR
Registry ID
SLCTR/2014/010
Enrollment
Unknown
Registered
2014-05-26
Start date
2014-05-26
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Incomplete and missed miscarriage

Interventions

Prospective participants presenting to the study setting will be evaluated by the Principal Investigator. Medical or surgical management will be decided on the following criteria 1) Patients presenti

Sponsors

University Obstetrics and Gynaecology Unit,
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Woman who present to ward NO: 03, T.H .Peradeniya (Gynaecology Professorial Unit) with incomplete and missed miscarriage diagnosed by Trans vaginal ultrasound as below: 1. Incomplete miscarriage: thickness of products of conception is > 1.5 cm 2. Missed miscarriage: Gestational sac >25mm without fetal pole or fetal pole CRL> 7mm without heart beat

Exclusion criteria

Exclusion criteria: 1. Signs and symptoms of infection including • Temperature > 37 0C • Lower abdominal tenderness • Offensive vaginal discharge • Cervical excitation 2. Known allergy to doxycycline 3. POG=/< than 24 weeks.

Design outcomes

Primary

MeasureTime frame
Clinical signs of infection (at least 3 of the following) 1. In the history: fever, chills, headache, lower abdominal pain and smelly vaginal discharge. 2. Temperature >37 degrees C. 3. Lower abdominal tenderness. 4. Positive cervical excitation test with or without adenexial tenderness. 5. Presence of smelly vaginal discharge. [At completion of three days and at 2 weeks post intervention]

Secondary

MeasureTime frame
None [None]

Countries

Sri Lanka

Contacts

Public ContactDr. D.P.G.G.M. Prasanga

Registrar, Gynaecology and Obstetrics

prasangagayan@yahoo.com

Outcome results

None listed

Source: SLCTR (via WHO ICTRP) · Data processed: Aug 9, 2026